It is used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. Zegerid OTC® is the only 24-hour frequent heartburn treatment that contains two active ingredients: the leading prescription acid reducer (omeprazole), plus a second ingredient (sodium bicarbonate) that protects the omeprazole from acid in the stomach — so it can be absorbed by the body and get right to work treating frequent heartburn. Zegerid (Omeprazole, Sodium Bicarbonate) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Zegerid (omeprazole / sodium bicarbonate) is a combination medication used to treat conditions related to having too much stomach acid. This medication is typically taken by mouth once daily. Zegerid OTC (omeprazole and sodium bicarbonate) is used to treat episodes of frequent heartburn. Includes Zegerid OTC side effects, interactions and indications. Zegerid OTC acid reflux medicine provides 24-hour protection from burning discomfort when taken once daily before eating. Each capsule contains a proton pump inhibitor (PPI) clinically proven to reduce acid at the source. Zegerid OTC Acid Reducer increases absorption of its active ingredient, Omeprazole, to quickly alleviate painful symptoms caused by frequent heartburn. When taken as recommended, Zegerid OTC Acid Reducer gently and effectively calms stomach acid and helps to prevent heartburn and acid reflux. Zegerid is used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD). Zegerid is also used to treat certain type of ulcers, or to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Shop for Zegerid in Antacids and Heartburn Relief. Buy products such as Zegerid OTC 24-Hour Heartburn Relief, Stomach Acid Reducer, The Only Proton Pump Inhibitor with Omeprazole 20mg + Sodium Bicarbonate, Treats Frequent Heartburn, 42ct Capsules at Walmart and save. Find patient medical information for Omeprazole/Sodium bicarbonate (Konvomep, Zegerid) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.