Zegerid OTC (omeprazole and sodium bicarbonate) is used to treat episodes of frequent heartburn. Includes Zegerid OTC side effects, interactions and indications. Zegerid OTC® is the only 24-hour frequent heartburn treatment that contains two active ingredients: the leading prescription acid reducer (omeprazole), plus a second ingredient (sodium bicarbonate) that protects the omeprazole from acid in the stomach — so it can be absorbed by the body and get right to work treating frequent heartburn. ZEGERID Capsules and Powder for Oral Suspension are immediate-release formulations that contain sodium bicarbonate which raises the gastric pH and thus protects omeprazole from acid degradation. TIME-Cap Labs Esomeprazole Magnesium 20mg Delayed-Release Capsules 42 Count | Three 14-day courses of treatment | Help treat Frequent Heartburn | May take 1 to 4 Days for Full Effect. Zegerid (omeprazole / sodium bicarbonate) is a combination medication used to treat conditions related to having too much stomach acid. This medication is typically taken by mouth once daily. ZEGERID capsules and ZEGERID for oral suspension are immediate-release formulations that contain sodium bicarbonate which raises the gastric pH and thus protects omeprazole from acid degradation. Shop Zegerid Over The Counter Heartburn Relief, 24 Hour Stomach Acid Reducer Capsules and read reviews at Walgreens. Pickup & Same Day Delivery available on most store items. Zegerid is used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD). Zegerid is also used to treat certain type of ulcers, or to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Zegerid (Omeprazole, Sodium Bicarbonate) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Overview: Omeprazole/sodium bicarbonate is used for heartburn, acid reflux, and ulcers, among other uses. Omeprazole decreases the amount of acid your stomach makes, while sodium bicarbonate is an.